Articles: Association of An Intronic, but Not Any Exonic, FRMD4B Sequence Variant and Heart Failure

Is there any difference between Vitamin D deficiency among heart failure and Non-heart failure elderly with cardiovascular disease?

Vitamin D deficiency is common among the elderly with and without heart failure (HF). This study was designed to identify the degree of vitamin D deficiency among HF and Non- HF elderly with cardiovascular disease. In this study, fifty hospitalized elderly patients with HF (26 women and 24 men, age range 60-90 years) and fifty elderly without HF were randomly selected. The level of serum 25-hyd...

Heart failure: not just the heart but also the lungs.

Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).

Increased adiposity is a major risk factor for cardiovascular disease and NIDDM (1). Genetic determinants of the degree of adiposity and body fat distribution have been demonstrated by twin and adoption studies, and the heritability (h) of obesity has been estimated to be as high as 0.90 (2). However, the major genes underlying the heritable contribution to body fatness in humans have remained ...

Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.

Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene evolved bimodal expression of constitutive (Homer 1b and c) and immediate early gene (IEG) products (Homer 1a and Ania 3). The IEG forms compete functionally with the constitutive Homer proteins. The comp...

Common variants in HSPB7 and FRMD4B associated with advanced heart failure.

BACKGROUND Heart failure results from abnormalities in multiple biological processes that contribute to cardiac dysfunction. We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk. METHODS AND RESULTS We used the ITMAT/Broad/CARe cardiovascular single-nucleotide polymorphism array to screen referral ...